Our new Clear+ tissue clearing technique is the only real approach that delipidates samples with no adjust in morphology and with negligible impact on structural integrity.

Megatome is often a vibrating microtome made to segment a wide variety of samples, from organoids and biopsy samples to expanded rodent brains and intact human organs. With high blade vibrating frequency and minimized blade deflection, Megatome enables substantial-throughput tissue sectioning with uniform area profile, in addition to nominal tissue problems and knowledge loss.

Antibodies may perhaps choose months to diffuse as a result of only some millimeters of tissue, by using a steep labeling gradient from area to Main.

Megatome is suitable for precision: the blade vibrates at a better frequency and larger amplitude assortment than other microtomes, and includes a unique deflection Management mechanism.

SE makes use of a rotational electric industry to disperse remarkably electromobile molecules (including antibodies or surfactant micelles) all through a porous sample without the need of detrimental electrically charged structures within the tissue. This permits 2-4 day clearing of intact organs,

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Megatome is actually a novel microtome that enables for prime-precision sectioning of a wide array of tissue samples – from organoids, to arrays of animal organs, to intact human Mind hemispheres – with nominal tissue damage and knowledge decline.

It’s the perfect time to enhance your microtome to Megatome. With exact higher-frequency slicing for an unmatched array of sample sizes and kinds – from organoids and tumors to expanded tissues, sample arrays, and intact primate organs – Megatome is optimized for varied applications.

The SmartSPIM light-weight sheet microscope offers unparalleled resolution and acquisition speed throughout intact tissue volumes, though its modular style and design means that you can enhance and customize person factors.

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SHIELD avoids the variability of hydrogel embedding and the knowledge decline from PFA preservation, protecting specimens for several rounds of processing.

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